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Communication
Chem. Commun., 2005, 400 - 402, DOI: 10.1039/b414474k
5-Hydroxyuracil can form stable base pairs with all four bases in a DNA duplex
Varatharasa Thiviyanathan, Anoma Somasunderam, David E. Volk and David G. Gorenstein
NMR studies, UV-monitored melting experiments, and ab initio calculations show that 5-hydroxyuracil, produced by the oxidative de-amination of cytosines by reactive oxygen species, can form stable base-pairs with dA, dG, dC and dT residues in a DNA duplex, providing a basis for the in-vivo incorporation of 5-hydroxyuracil during DNA replication.
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