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Chem. Commun., 2005, 4465 - 4467, DOI: 10.1039/b508151c


Pictet–Spengler reactions in multiphasic supercritical carbon dioxide/CO2-expanded liquid media. In situ generation of carbamates as a strategy for reactions of amines in supercritical carbon dioxide

Joshua R. Dunetz, Rocco P. Ciccolini, Morgan Fröling, Scott M. Paap, Andrew J. Allen, Andrew B. Holmes, Jefferson W. Tester and Rick L. Danheiser


Acyl-Pictet–Spengler cyclizations can be achieved in scCO2/CO2-expanded liquid media via the in situ formation of carbamate derivatives of -arylethylamines.

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