Issue 24, 2006
From the journal:

Chemical Communications

A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly

Ian R. Baxendale,a   Jon Deeley,a   Charlotte M. Griffiths-Jones,a   Steven V. Ley,*a   Steen Saabya  and  Geoffrey K. Tranmera  

* Corresponding authors

a Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: svl1000@cam.ac.uk
Fax: +44 1223 336442
Tel: +44 1223 336398

Abstract

A flow process for the multi-step synthesis of the alkaloid natural product (±)-oxomaritidine is described, mediated through the use of microfluidic pumping systems that progress material through various packed columns containing immobilized reagents, catalysts, scavengers or catch and release agents; our route involves the combination of seven separate synthetic steps linked into one continuous sequence utilizing flow chemistry.

Graphical abstract: A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly

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Article information

DOI
https://doi.org/10.1039/B600382F
Article type
Communication
Submitted
11 Jan 2006
Accepted
03 Feb 2006
First published
24 Mar 2006

Chem. Commun., 2006, 2566-2568

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A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly

I. R. Baxendale, J. Deeley, C. M. Griffiths-Jones, S. V. Ley, S. Saaby and G. K. Tranmer, Chem. Commun., 2006, 2566 DOI: 10.1039/B600382F

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