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Chem. Commun., 2006, 2353 - 2355, DOI: 10.1039/b601202g

Are branched chain fatty acids the natural substrates for P450BM3?

Max J. Cryle, Rocio D. Espinoza, Sarah J. Smith, Nicholas J. Matovic and James J. De Voss

Branched chain fatty acids are substrates for cytochrome P450BM3 (CYP102) from Bacillus megaterium; oxidation of C15 and C17iso and anteiso fatty acids by P450BM3 leads to the formation of hydroxylated products that possess high levels of regiochemical and stereochemical purity.

Graphical abstract image for this article (ID: b601202g)