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Chem. Commun., 2006, 3104 - 3106, DOI: 10.1039/b604040c

Direct evidence for enzyme persulfide and disulfide intermediates during 4-thiouridine biosynthesis

Chapman M. Wright, Glenn D. Christman, Ann M. Snellinger, Murray V. Johnston and Eugene G. Mueller

Two proposed mechanisms for 4-thiouridine generation share key cysteine persulfide and disulfide intermediates, and indirect evidence of their existence has been previously reported; chemical trapping and mass spectrometry have now provided direct and definitive evidence of these key intermediates.

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