Communication

Chem. Commun., 2007, 2054 - 2056, DOI: 10.1039/b618568a

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Archaeosomes based on synthetic tetraether-like lipids as novel versatile gene delivery systems

G. Réthoré, T. Montier, T. Le Gall, P. Delépine, S. Cammas-Marion, L. Lemiègre, P. Lehn and T. Benvegnu

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Novel cationic liposomes, termed archaeosomes, based on mixtures of neutral/cationic bilayer-forming lipids and archaeobacterial synthetic tetraether-type bipolar lipids show efficient in vitro gene transfection properties and represent a new approach for modulating the lipidic membrane fluidity of the complexes they form with DNA.

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