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Communication
Chem. Commun., 2007, 1518 - 1520, DOI: 10.1039/b702826a
Activity-based fingerprinting and inhibitor discovery of cysteine proteases in a microarray
Mahesh Uttamchandani, Kai Liu, Resmi C. Panicker and Shao Q. Yao
A panel of 20 peptide vinyl sulfone probes has been synthesized and used to generate activity-based fingerprinting profiles of cysteine proteases in both gel- and microarray-based formats; the inhibitor fingerprints of representative small molecule inhibitors targeted against 4 cysteine proteases were also obtained, in high-throughput, using the same protein microarray platform.
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