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Chem. Commun., 2007, 4647 - 4649, DOI: 10.1039/b713190a

Activity-based fluorescent reporters for monoamine oxidases in living cells

Aaron E. Albers, Katherine A. Rawls and Christopher J. Chang

Monoamine Oxidase Reporters 1 and 2 (MR1 and MR2) are substrate-tethered activity probes that utilize a tandem amine oxidation/-elimination mechanism to detect MAO chemistry in vitro and in living cells directly and specifically without the need for additional enzymes or other activating reagents.

Graphical abstract image for this article (ID: b713190a)