RSC Publishing


Publishing

 

Cover image for Chemical Communications, select for current issue

Chemical Communications

Urgent high quality communications from across the chemical sciences.



Subscribers

  • PDF
  • HTML article

Non-subscribers

Free access



Communication

Chem. Commun., 2008, 3055 - 3057, DOI: 10.1039/b806042h

G-quadruplex recognition by bis-indole carboxamides

Jyotirmayee Dash, Pravin S. Shirude and Shankar Balasubramanian

Herein we report the de novo design and synthesis of a geometrically flexible bis-indole carboxamide and a constrained derivative, as a novel class of small molecule scaffold that exhibits high stabilization potential for DNA G-quadruplex sequences associated with the promoters of c-kit2 and c-myc.

Graphical abstract image for this article (ID: b806042h)