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Chem. Commun., 2010, 46, 216 - 218, DOI: 10.1039/b915775a

Spontaneous and reversible self-assembly of a polypeptide fragment of insulin-like growth factor binding protein-2 into fluorescent nanotubular structures

Monalisa Swain, R. Thirupathi, B. Krishnarjuna, Erin M. Eaton, Megan M. Kibbey, Steven A. Rosenzweig and Hanudatta S. Atreya

In this communication, we report the spontaneous and reversible in vitro self-assembly of a polypeptide fragment derived from the C-terminal domain of Insulin-like Growth Factor Binding Protein (IGFBP-2) into soluble nanotubular structures several micrometres long via a mechanism involving inter-molecular disulfide bonds and exhibiting enhanced fluorescence.

Graphical abstract image for this article (ID: b915775a)