Communication

Chem. Commun., 2010, 46, 333 - 335, DOI: 10.1039/b916307g

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¹³C Labeling reveals multiple amination reactions in the biosynthesis of a novel polyketide polyamine antibiotic zeamine from Dickeya zeae

Jien Wu, Hai-Bao Zhang, Jin-Ling Xu, Russell J. Cox, Thomas J. Simpson and Lian-Hui Zhang

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The structure of zeamine, a novel polyamino-amide antibiotic metabolite of Dickeya zeae has been established by NMR and detailed MS analyses; labelling studies with ¹³C-labelled acetates suggest that the repeating secondary amine containing motif may be biosynthesised via a modular PKS containing aminotransferase domains.

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