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Communication

Chem. Commun., 2009, 7399 - 7401, DOI: 10.1039/b916751j

Products of the iterative polyketide synthases in 9- and 10-membered enediyne biosynthesis

Huihua Sun, Rong Kong, Di Zhu, Min Lu, Qiang Ji, Chong Wai Liew, Julien Lescar, Guofu Zhong and Zhao-Xun Liang

The iterative polyketide synthases from the biosynthetic pathways of three enediyne natural products were examined. The results established the all-trans conjugated pentadecaheptanene as the only major product shared by the PKSs. The experiments further revealed some intrinsic differences among the PKSs by demonstrating the formation of different by-products.

Graphical abstract image for this article (ID: b916751j)