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Communication
Chem. Commun., 2010, 46, 97 - 99, DOI: 10.1039/b917797c
Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition
Marjoke F. Debets, Sander S. van Berkel, Sanne Schoffelen, Floris P. J. T. Rutjes, Jan C. M. van Hest and Floris L. van Delft
A strained aza-dibenzocyclooctyne was prepared via a high-yielding synthetic route. Copper-free, strain-promoted click reaction with azides showed excellent kinetics, and a functionalised aza-cyclooctyne was applied in fast and efficient PEGylation of enzymes.
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