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Chem. Commun., 2010, 46, 130 - 132, DOI: 10.1039/b917958e

Synthesis of 3-hydroxyoxindoles by Pd-catalysed intramolecular nucleophilic addition of aryl halides to -ketoamides

Yi-Xia Jia, Dmitry Katayev and E. Peter Kündig

Pd/PtBu3-catalysed intramolecular nucleophilic addition of aryl halides to -ketoamides in the presence of nBuOH and base has been realized with high yields, providing a new, direct, and efficient synthetic strategy to obtain 3-hydroxyoxindoles.

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