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Chem. Commun., 2010, 46, 460 - 462, DOI: 10.1039/b918330b

Unique metabolites of Pestalotiopsis fici suggest a biosynthetic hypothesis involving a Diels–Alder reaction and then mechanistic diversification

Ling Liu, Shubin Niu, Xinhua Lu, Xulin Chen, Hua Zhang, Liangdong Guo and Yongsheng Che

Chloropupukeanolides A ( 1) and B ( 2), unprecedented spiroketal peroxides, and chloropupukeanone A ( 3), three highly functionalized metabolites featuring a chlorinated pupukeanane core, were isolated from an endophytic fungus Pestalotiopsis fici, with 1 showing significant anti-HIV-1 and cytotoxic effects.

Graphical abstract image for this article (ID: b918330b)