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Article citation: Qian Cai, Chem. Commun., 2009, DOI: 10.1039/b918345k

Assembly of indole-2-carboxylic acid esters through a ligand-free copper-catalysed cascade process

Qian Cai, Zhengqiu Li, Jiajia Wei, Chengyong Ha, Duanqing Pei and Ke Ding

A straightforward synthesis of indole-2-carboxylic esters was developed through a ligand-free copper-catalysed condensation/coupling/deformylation cascade process from 2-halo aryl aldehydes or ketones with ethyl isocyanoacetate. The reactions proceeded well for most of the 2-iodo-, bromo-, and chloro-subtrates under room temperature or mild conditions.

Graphical abstract image for this article (ID: b918345k)