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Communication
Chem. Commun., 2009, 7581 - 7583, DOI: 10.1039/b918345k
Assembly of indole-2-carboxylic acid esters through a ligand-free copper-catalysed cascade process
Qian Cai, Zhengqiu Li, Jiajia Wei, Chengyong Ha, Duanqing Pei and Ke Ding
A straightforward synthesis of indole-2-carboxylic esters was developed through a ligand-free copper-catalysed condensation/coupling/deformylation cascade process from 2-halo aryl aldehydes or ketones with ethyl isocyanoacetate. The reactions proceeded well for most of the 2-iodo-, bromo-, and chloro-subtrates under room temperature or mild conditions.
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