Communication

Chem. Commun., 2010, 46, 139 - 141, DOI: 10.1039/b919364b

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An enzymatic route to 5-deoxy-5-[¹⁸F]fluoro-D-ribose, a [¹⁸F]-fluorinated sugar for PET imaging

Mayca Onega, Juozas Domarkas, Hai Deng, Lutz F. Schweiger, Timothy A. D. Smith, Andrew E. Welch, Christophe Plisson, Antony D. Gee and David OHagan

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An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5-[¹⁸F]fluororibose, a novel [¹⁸F]-fluorinated sugar suitable for positron emission tomography (PET) applications.

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