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Chem. Commun., 2010, 46, 637 - 639, DOI: 10.1039/b919815f

Chemical rescue of protein tyrosine phosphatase activity

Vincent L. Chen and Anthony C. Bishop

We report that the activity of a rationally engineered protein tyrosine phosphatase (PTP) mutant can be fully rescued by the addition of the biarsenical fluorescein derivative FlAsH, a compound that does not affect the activity of wild-type PTPs.

Graphical abstract image for this article (ID: b919815f)