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Tutorial Review
Chem. Soc. Rev., 2008, 37, 1320 - 1329, DOI: 10.1039/b702780j
Small molecule inhibition of microbial natural product biosynthesis—an emerging antibiotic strategy
Justin S. Cisar and Derek S. Tan
A variety of natural products modulate critical biological processes in the microorganisms that produce them. Thus, inhibition of the corresponding natural product biosynthesis pathways represents a promising avenue to develop novel antibiotics. In this tutorial review, we describe several recent examples of designed small molecule inhibitors of microbial natural product biosynthesis and their use in evaluating this emerging antibiotic strategy.
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