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Critical Review
Chem. Soc. Rev., 2008, 37, 1432 - 1447, DOI: 10.1039/b703021p
Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria
Grant D. Geske, Jennifer C. O
Neill and Helen E. Blackwell
Bacteria are capable of
communicating
their local population densities via a process termed quorum sensing (QS). Gram-negative bacteria use N-acylated L-homoserine lactones (AHLs), in conjunction with their cognate LuxR-type receptors, as their primary signalling circuit for QS. In this critical review, we examine AHL signalling in Gram-negative bacteria with a primary focus on the design of non-natural AHLs, their structure-activity relationships, and their application in chemical biological approaches to study QS (72 references).
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