_tcm18-11400.gif )
The home of high impact reviews from across the chemical sciences.
Tutorial Review
Article citation: Fabian Pfrengle, Chem. Soc. Rev., 2010, DOI: 10.1039/b914356d
Amino sugars and their mimetics via 1,2-oxazines
Fabian Pfrengle and Hans-Ulrich Reissig
This tutorial review covers recent research from our laboratory towards the synthesis of amino sugars and related carbohydrate mimetics employing 1,2-oxazines as crucial intermediates. The synthesis of new dideoxyamino carbohydrate derivatives, C2-branched 4-amino sugars and their mimetics, as well as sialic acid analogues, has been developed during the last few years. The results demonstrate that alkoxyallenes are ideal and versatile components for the chain elongation of carbohydrate derivatives. Our routes starting from 3,6-dihydro-2H-1,2-oxazines are presented in conjunction with two related examples from the recent literature. Finally, we discuss possible future applications of the described compounds as anti-inflammatory agents.
RSS feed