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The international journal for inorganic, organometallic and bioinorganic chemistry
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Dalton Trans., 2007, 2734 - 2745, DOI: 10.1039/b704360k
Metal complexes of cyclen and cyclam derivatives useful for medical applications: a discussion based on thermodynamic stability constants and structural data
Rita Delgado, Vítor Félix, Luís M. P. Lima and David W. Price
A series of the most common chelators used in magnetic resonance imaging (MRI) and in radiopharmaceuticals for medical diagnosis and tumour therapy, H4dota, H4teta, H8dotp and H8tetp, is examined from a chemical point of view. Differences between 12- and 14-membered tetraazamacrocyclic derivatives with methylcarboxylate and methylphosphonate pendant arms and their chelates with divalent first-series transition metal and trivalent lanthanide ions are discussed on the basis of their thermodynamic stability constants, X-ray structures and theoretical studies.
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