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Paper
Dalton Trans., 2010, 39, 185 - 191, DOI: 10.1039/b917673j
Densely packed Gd(III)-chelates with fast water exchange on a calix[4]arene scaffold: a potential MRI contrast agent
Daniel T. Schühle, Miloslav Polá
ek, Ivan Luke, Thomas Chauvin, Éva Tóth, Jürgen Schatz, Ulf Hanefeld, Marc C. A. Stuart and Joop A. Peters
A pyridine-N-oxide functionalized DOTA analogue has been conjugated to a calix[4]arene and the corresponding Gd-complex was characterized with respect to its suitability as MRI contrast agent. The compound forms spherical micelles in water with a cmc of 35
M and a radius of 8.2 nm. The relaxivity of these aggregates is 31.2 s-1 mM-1 at 25 °C and 20 MHz, which corresponds to a molecular relaxivity of 125 s-1 mM-1. The high relaxivity mainly originates from the short 
M (72.7 ns) and the size of the micelles. The interaction with bovine serum albumin (BSA) was studied and an observed relaxivity of up to 40.8 s-1 mM-1 (163.2 s-1 mM-1 per binding place) at 20 MHz and 37 °C was found in the presence of 2.0 mM protein.
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