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The international journal for inorganic, organometallic and bioinorganic chemistry
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Paper
Dalton Trans., 2009, 10914 - 10925, DOI: 10.1039/b918902e
Synthesis, molecular structure and evaluation of new organometallic ruthenium anticancer agents
Kenneth D. Camm, Ahmed El-Sokkary, Andrew L. Gott, Peter G. Stockley, Tamara Belyaeva and Patrick C. McGowan
A number of new ruthenium compounds have been synthesised, isolated and characterised, which exhibit excellent cytotoxicity against a number of different human tumour cell lines including a defined cisplatin resistant cell line and colon cancer cell lines. Addition of hydrophobic groups to the ruthenium molecules has a positive effect on the cytotoxicity values. Evidence is provided that, after incubation of a ruthenium compound with a 46 mer oligonucleotide duplex and subsequent nuclease treatment, ruthenium is bound to a guanine residue.
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