Issue 11, 2010
From the journal:

Dalton Transactions

Issues surrounding standard cytotoxicity testing for assessing activity of non-covalent DNA-binding metallo-drugs†

Alexandra. J. Pope,a   Christopher Bruce,b   Boris Kyselab  and  Michael. J. Hannon*a  

* Corresponding authors

a School of Chemistry, University of Birmingham, Birmingham, UK
E-mail: m.j.hannon@bham.ac.uk
Fax: +44 121 414 4403
Tel: +44 121 414 2527

b School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Section of Medical and Molecular Genetics, University of Birmingham, Edgbaston, Birmingham, UK

Abstract

Investigating the methods commonly used to evaluate in vitro cytotoxicity of novel compounds, specifically non-covalent DNA binders, identifies that these methods may not be appropriate. The level of anticancer activity depends not only on the incubation time but also on the absolute amount (number of moles) of drug compound applied, rather than the concentration.

Graphical abstract: Issues surrounding standard cytotoxicity testing for assessing activity of non-covalent DNA-binding metallo-drugs

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Article information

DOI
https://doi.org/10.1039/B927129P
Article type
Communication
Submitted
22 Dec 2009
Accepted
26 Jan 2010
First published
05 Feb 2010

Dalton Trans., 2010,39, 2772-2774

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Issues surrounding standard cytotoxicity testing for assessing activity of non-covalent DNA-binding metallo-drugs

Alexandra. J. Pope, C. Bruce, B. Kysela and Michael. J. Hannon, Dalton Trans., 2010, 39, 2772 DOI: 10.1039/B927129P

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