Issue 10, 2004
From the journal:

Green Chemistry

Continuous catalytic asymmetric hydrogenation in supercritical CO2

Phil Stephenson,a   Peter Licence,*a   Stephen K. Rossb  and  Martyn Poliakoff*a  

* Corresponding authors

a School of Chemistry, The University of Nottingham, University Park, Nottingham, UK
E-mail: martyn.poliakoff@nottingham.ac.uk
Fax: +44 115 951 3058
Tel: +44 115 951 3386

b Thomas Swan & Co., Ltd., Crookhall, Consett, UK
E-mail: sross@thomas-swan.co.uk
Fax: +44 1207 590467
Tel: +44 1207 505131

Abstract

Continuous hydrogenation in supercritical fluids has been shown to be a technically viable alternative to traditional batch-wise methodologies. Clearly, the next stage of development of this technology is the application of immobilised enantioselective catalysis in the preparation of optically active products. Enantioselective hydrogenation has been successfully carried out in supercritical carbon dioxide using batch-type reactors but has yet to be efficiently carried out continuously. Here we examine an established method of catalyst immobilisation and demonstrate its suitability for application in continuous reactors using supercritical carbon dioxide as solvent.

Graphical abstract: Continuous catalytic asymmetric hydrogenation in supercritical CO2

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Article information

DOI
https://doi.org/10.1039/B411955J
Article type
Paper
Submitted
03 Aug 2004
Accepted
04 Aug 2004
First published
29 Sep 2004

Green Chem., 2004,6, 521-523

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Continuous catalytic asymmetric hydrogenation in supercritical CO2

P. Stephenson, P. Licence, S. K. Ross and M. Poliakoff, Green Chem., 2004, 6, 521 DOI: 10.1039/B411955J

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