Issue 10, 2009

Parylene peel-off arrays represent a simple and reproducible micropatterning approach to spatiotemporally control cell-cell interactions and study their impact on the angiogenic capability of tumour cells. Image reproduced by permission of Christine P. Tan, Bo Ri Seo, Daniel J. Brooks, Emily M. Chandler, Harold G. Craighead and Claudia Fischbach
DOI: 10.1039/B908036H

Issue 8/9, 2009

Cancer cells mechanically confined in small channels display spontaneous persistent motility in the absence of external gradients. Image reproduced by permission of Daniel Irimia and Mehmet Toner
DOI: 10.1039/B908595E

Issue 8/9, 2009 (Inside)

Novel high throughput cellular array technology is used to assess t he complex relationships between hepatic stellate cells and components of their microenvironment. Image reproduced by permission of David A. Brafman, Samuele de Minicis, Ekihiro Seki, Kevan D. Shah, Dayu Teng, David Brenner, Karl Willert and Shu Chien
DOI: 10.1039/B916632g

Issue 7, 2009

The image shows the heterogeneous distribution of deformation in a triple helical tropocollagen molecule under mechanical stress. The peaks and valleys show soft and stiff regions in the molecule, respectively. Image reproduced by permission of Markus Buehler

Issue 7, 2009 (Inside)

The goal of our work is to develop novel cell culture surfaces that provide "instructive" cues for embryonic stem cell differentiation towards hepatic lineage. Image reproduced by permission of Alexander Revzin

Issue 5-6, 2009

The cover depicts different aspects of activatable cell penetrating peptides as probes that can be used to image endogenous disease associated protease activity, in this case MMPs in cancer. Image reproduced by permission of Todd A. Aguilera, Emilia S. Olson, Margaret M. Timmers, Tao Jiang and Roger Y. Tsien from Integrative Biology, 2009, 1, 371.

Issue 5-6, 2009 (Inside)

Beads, each coated with a different antigen, are reacted in a single vessel with a sample containing unknown antibodies. Blue fluorescence indicates antibody binding. Bound antibody is identified by a unique code on each bead. Image reproduced by permission of Sam Birtwell and Hywell Morgan

Issue 4, 2009

A new screening and analytic approach identifies nanoparticles that best discriminate between two classes of human primary cell isolates, enabling the unbiased discovery of novel invivo imaging probes. Image reproduced by permission of Kimberly A. Kelly, Stanley Y. Shaw, Matthias Nahrendorf, Kelly Kristoff, Elena Aikawa, Stuart L. Schreiber, Paul A. Clemons and Ralph Weissleder from Integr. Biol., 2009, 1, 311.
DOI: 10.1039/B821775K

Issue 4, 2009 (Inside)

This article investigates the mechanism of SNARE-mediated membrane fusion using an atomic force microscope-based experimental system for membrane fusion. Image reproduced by permission of Midhat H. Abdulreda, Akhil Bhalla, Felix Rico, Per-Olof Berggren, Edwin R. Chapman and Vincent T. Moy from Integr. Biol., 2009, 1, 301.
DOI: 10.1039/B905042F

Issue 3, 2009

A close look at the compaction of collagen gels by embedded cells reveals much more life in the extracellular matrix than hitherto realized. Image reproduced by permission of Pablo Fernandez and Andreas R. Bausch from Integr. Biol., 2009, 1, 252.
DOI: 10.1039/B822897C

Issue 3, 2009 (Inside)

Living specialised and unspecialised scaffold-based microenvironments containing a wide range of primary and/or stem cells. Image reproduced by permission of Anil Abeyewickreme, Albert Kwok, Jean R. McEwan and Suwan N. Jayasinghe from Integr. Biol., 2009, 1, 260.
DOI: 10.1039/b904099b

Issue 2, 2009

New method of tissue engineering: Corneal fibroblasts cultured on micropatterned biomaterials in spontaneous organization of cells and extracellular matrix in patterns consistent with the tissue of origin. Image reproduced by permission of Maxime D. Guillemette, Bo Cui, Emmanuel Roy, Robert J. Gauvin, Claude J. Giasson, Mandy B. Esch,
Patrick Carrier, Alexandre Deschambeault, Michel Dumoulin, Mehmet Toner, Lucie Germain, Teodor Veres and Francois A. Auger from Integr. Biol., 2009, 1, 196.
DOI: 10.1039/B820208G

Issue 1, 2009

Bioengineered hydrogel microarrays, microcontact printing and single cell time-lapse microscopy reveal the rols of individual niche components in hematopoietic stem cell self-renewal. Image reproduced by permission of Helen Blau and Stephane Corbel from Matthias P. Lutolf, Regis Doyonnas, Karen Havenstrite, Kassie Koleckar. Integr. Biol., 2009, 1, 59.
DOI: 10.1039/B815718A

Issue 1, 2009 (Inside)

The generation of a bilayered terminal duct lobular unit from a single human mammary progenitor cell in three-dimensional culture requires the appropriate presentation of instructive microenvironmental molecules. Image reproduced by permission of mark A. Labarge, Celeste M. Nelson, Rene Villadsen, Agla Fridriksdottir, Jason R. Ruth, Martha R. Stampfer, Ole W. Petersen and Mina J. Bissell from Integr. Biol., 2009, 1, 70.
DOI: 10.1039/b822122g