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Modelling viruses to kill cancer
17 November 2009
Computational studies of virus behaviour in tumours could lead to more effective cancer treatments
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Contents list for Integrative Biology, issue 11-12, 2009
Front cover
Integr. Biol., 2009, 1, 617
DOI: 10.1039/b923633n
Inside front cover
Integr. Biol., 2009, 1, 618
DOI: 10.1039/b923634c
Contents
Integr. Biol., 2009, 1, 619
DOI: 10.1039/b923635j
Focus
Integration column: microwell arrays for mammalian cell culture
Mirren Charnley, Marcus Textor, Ali Khademhosseini and Matthias P. Lutolf,
Integr. Biol., 2009, 1, 625
DOI: 10.1039/b918172p
Microwell arrays are emerging as cell culture substrates to probe and manipulate cell fate. Key applications of these platforms are critically discussed in this column—part of a series of mini-reviews covering integration of new tools and technologies for the benefit of biology.
Papers
Crosslinking of cell-derived 3D scaffolds up-regulates the stretching and unfolding of new extracellular matrix assembled by reseeded cells
Kristopher E. Kubow, Enrico Klotzsch, Michael L. Smith, Delphine Gourdon, William C. Little and Viola Vogel,
Integr. Biol., 2009, 1, 635
DOI: 10.1039/b914996a
FRET-labeled fibronectin was incorporated as an intramolecular mechanical strain sensor to probe in real-time how cells stretch the 3D scaffold as well as the newly deposited matrix.
Microfluidic hydrodynamic cellular patterning for systematic formation of co-culture spheroids
Yu-suke Torisawa, Bobak Mosadegh, Gary D. Luker, Maria Morell, K. Sue O
Shea and Shuichi Takayama,
Integr. Biol., 2009, 1, 649
DOI: 10.1039/b915965g
A microfluidic system for formation of patterned co-culture spheroids. Five distinct cell groups are patterned into 
human
shapes. Janus co-culture spheroids trigger patterned differentiation of mouse embryonic stem cells.
The dual nature of extracellular ATP as a concentration-dependent platelet P2X1 agonist and antagonist
Welvitya Karunarathne, Chia-Jui Ku and Dana M. Spence,
Integr. Biol., 2009, 1, 655
DOI: 10.1039/b909873a
ATP inhibits and stimulates platelet aggregation in a concentration-dependent manner, thus implicating the erythrocyte as a determinant of platelet behavior in vivo.
Dynamics of virus spread in the presence of fluid flow
Samartha G. Anekal, Ying Zhu, Michael D. Graham and John Yin,
Integr. Biol., 2009, 1, 664
DOI: 10.1039/b908197f
Enhanced HTML article available
Comet-like patterns of viral infection spread are formed by the coupling of virus reproduction with fluid flows. Experiments and theory are developed here to understand these patterns.
Highlights in Chemical Biology and back matter
Integr. Biol., 2009, 1, 672
DOI: 10.1039/b923646p
Back cover
Integr. Biol., 2009, 1, 675
DOI: 10.1039/b923636h
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