Journal of the Chemical Society C: Organic
Journal of the Chemical Society C: Organic was published between 1966 - 1971.
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Paper
J. Chem. Soc. C, 1971, 3047 - 3048, DOI: 10.1039/J39710003047
An efficient preparation of isocodeine from codeine
G. W. Kirby and S. R. Massey
Codeine has been converted into isocodeine in overall yields of 65–70%. Codeine toluene-p-sulphonate reacted in benzene with hexadecyltrimethylammonium acetate to give isocodeine acetate, which was hydrolysed to isocodeine. Reinecke's salt was used to remove the hexadecyltrimethylammonium cation from the reaction mixture. The codeine content of the purified isocodeine was assayed by radiodilution techniques.
