Issue 19, 2009
From the journal:

Journal of Materials Chemistry

Gold-layered calcium phosphate plasmonic resonants for localized photothermal treatment of human epithelial cancer†

Jinyoung Kang,ab   Jaemoon Yang,ac   Jaewon Lee,a   Seung Jae Oh,c   Seyoung Moon,bf   Hong Jae Lee,d   Sang Cheon Lee,d   Joo-Hiuk Son,e   Donghyun Kim,f   Kwangyeol Lee,g   Jin-Suck Suh,c   Yong-Min Huh*c  and  Seungjoo Haam*a  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, Republic of Korea
Fax: +82-2-312-6401
Tel: +82-2-2123-2751

b Program for Nanomedical Science and Technology, Yonsei University, Seoul, Republic of Korea

c Department of Radiology, College of Medicine, Yonsei University, Seoul, Republic of Korea

d Department of Oral Biology & Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul, Republic of Korea

e Department of Physics, University of Seoul, Seoul, Republic of Korea

f Department of Electrical and Electronic Engineering, Yonsei University, Seoul, Republic of Korea

g Department of Chemistry, Korea University, Seoul, Republic of Korea

Abstract

We fabricated de novo biocompatible mineral plasmon resonants for localized and systemic treatment of cancer. Biodegradable calcium-phosphate gold nanocomposites were synthesized for inducing a superior surface plasmon resonance effect. The combination of therapeutic antibody, Erbitux® and NIR laser with nanocomposites demonstrated the potential for selective bimodal cancer treatment by combination of EGFR-induced signaling inhibition as a systemic treatment and localized photothermal effects caused by the NIR laser.

Graphical abstract: Gold-layered calcium phosphate plasmonic resonants for localized photothermal treatment of human epithelial cancer

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B822835C
Article type
Communication
Submitted
19 Dec 2008
Accepted
24 Mar 2009
First published
06 Apr 2009

J. Mater. Chem., 2009,19, 2902-2905

Permissions

Request permissions

Gold-layered calcium phosphate plasmonic resonants for localized photothermal treatment of human epithelial cancer

J. Kang, J. Yang, J. Lee, S. J. Oh, S. Moon, H. J. Lee, S. C. Lee, J. Son, D. Kim, K. Lee, J. Suh, Y. Huh and S. Haam, J. Mater. Chem., 2009, 19, 2902 DOI: 10.1039/B822835C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements