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Soft Matter

Physics, chemistry and biology of Soft Matter

Communication

J. Mater. Chem., 2010, 20, 444 - 447, DOI: 10.1039/b918416c

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Complete separation of magnetic nanoparticles via chemical cleavage of dextran by ethylenediamine for intracellular uptake

Meng Meng Lin, Shanghua Li, Hyung-Hwan Kim, Hyuck Kim, Hyung Bock Lee, Mamoun Muhammed and Do Kyung Kim

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Completely water dispersible and highly monodispersed superparamagnetic iron oxide nanoparticles (SPIONs) were prepared. The surface of SPIONs was modified with dual-crosslinked amine activated dextran (AMD) and chemical cleavage of AMD on SPIONs was carried out by ethylenediamine hydrochloride (EDA). Transmission electron microscopy (TEM) revealed that individual SPIONs were completely separated in water and the average diameter of resulting nanoparticles was 4.4 nm.

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