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Latest News
Chips & Tips: Lamination of Plastic Microfluidic Devices
30 July 2008
Daniel Olivero and Z. Hugh Fan present a simple method for lamination of plastic microfluidic devices
Droplet traps for worms on chip
29 July 2008
Watching how worms behave in droplets is the basis for a new assay that could find use in high-throughput drug screening
Chips & Tips: Quick Measurement of Electroosmotic Flow Velocity
10 July 2008
Motohiko Nohmi and Juan Santiago present a simple way of estimating electroosmotic flow velocities in channel geometries with at least one intersection.
Contents list for Lab on a Chip, issue 9, 2008
Front cover
Lab Chip, 2008, 8, 1409
DOI: 10.1039/b813274g
Inside front cover
Lab Chip, 2008, 8, 1410
DOI: 10.1039/b813275p
Contents and Chemical Technology
Lab Chip, 2008, 8, 1411
DOI: 10.1039/b813276n
Highlight
Research Highlights
Lab Chip, 2008, 8, 1421
DOI: 10.1039/b812109p
Petra Dittrich reviews the current literature in miniaturisation and related technologies.
Focus
Simulation tools for lab on a chip research: advantages, challenges, and thoughts for the future
Lab Chip, 2008, 8, 1424
DOI: 10.1039/b812596c
Sumita Pennathur, David Boy and Frédéric Gibou discuss aspects of computation in lab on a chip research—part of a series of mini-reviews covering new trends in fundamental and applied research, and potential applications of miniaturised technologies.
Communications
Droplet-based microfluidic system for individual Caenorhabditis elegans assay
Weiwei Shi, Jianhua Qin, Nannan Ye and Bingcheng Lin,
Lab Chip, 2008, 8, 1432
DOI: 10.1039/b808753a
A new, droplet-based microfluidic system is reported for controllably encapsulating Caenorhabditis elegans into a parallel series of nanolitre-volume droplets and characterizing its behavior in response to neurotoxin. This system has the potential to accelerate the current whole-animal high-throughput assay and provide novel types of assay at single-animal resolution for drug discovery.
Millisecond denaturation dynamics of fluorescent proteins revealed by femtoliter container on micro-thermodevice
Hideyuki F. Arata, Frederic Gillot, Takahiko Nojima, Teruo Fujii and Hiroyuki Fujita,
Lab Chip, 2008, 8, 1436
DOI: 10.1039/b806749j
We used our own on-chip microheaters and microcontainers to observe the denaturation dynamics of fluorescent proteins at the millisecond time scale.
Papers
Setting up roadblocks for kinesin-1: mechanism for the selective speed control of cargo carrying microtubules
Till Korten and Stefan Diez,
Lab Chip, 2008, 8, 1441
DOI: 10.1039/b803585g
The speed of protein-coated microtubules gliding on a kinesin surface is determined by the density of the coating protein and can be used for differential detection.
Crossing microfluidic streamlines to lyse, label and wash cells
Keith J. Morton, Kevin Loutherback, David W. Inglis, Ophelia K. Tsui, James C. Sturm, Stephen Y. Chou and Robert H. Austin,
Lab Chip, 2008, 8, 1448
DOI: 10.1039/b805614e
Using an asymmetric post array in pressure-driven microfluidic flow, we can move particles of interest across multiple, independent chemical streams, enabling sequential chemical operations. With this method, we demonstrate on-chip cell treatments such as labeling and washing, and bacterial lysis and chromosomal extraction.
Novel inorganic polymer derived microreactors for organic microchemistry applications
Tae-Ho Yoon, Sang-Hee Park, Kyoung-Ik Min, Xunli Zhang, Stephen J. Haswell and Dong-Pyo Kim,
Lab Chip, 2008, 8, 1454
DOI: 10.1039/b804726j
Microreactors fabricated with optically transparent inorganic polymers using a UV-microimprinting process demonstrated reliable solvent resistance and capability for organic synthetic reactions.
Open micro-fluidic system for atomic force microscopy-guided in situ electrochemical probing of a single cell
WonHyoung Ryu, Zubin Huang, Joong Sun Park, Jeffrey Moseley, Arthur R. Grossman, Rainer J. Fasching and Fritz B. Prinz,
Lab Chip, 2008, 8, 1460
DOI: 10.1039/b803450h
We present an open micro-fluidic platform that immobilizes single cells in an array. The system enables in situ nano-scale electrochemical probing integrated with atomic force microscopy.
Design, fabrication and implementation of a novel multi-parameter control microfluidic platform for three-dimensional cell culture and real-time imaging
Vernella Vickerman, Jennifer Blundo, Seok Chung and Roger Kamm,
Lab Chip, 2008, 8, 1468
DOI: 10.1039/b802395f
A new microfluidic platform is introduced for 3D cell culture in biologically derived or synthetic hydrogels, with enhanced capabilities for monitoring cellular dynamics in response to changes in their biophysical and biochemical microenvironments.
Cell characterization using a protein-functionalized pore
Andrea Carbonaro, Swomitra K. Mohanty, Haiyan Huang, Lucy A. Godley and Lydia L. Sohn,
Lab Chip, 2008, 8, 1478
DOI: 10.1039/b801929k
Cells are screened for specific cell surface receptors using protein-functionalized pores. Individual cells transit pores and protein–protein interactions are probed electronically via resistive pulse sensing.
Microfluidic devices for studies of shear-dependent platelet adhesion
Edgar Gutierrez, Brian G. Petrich, Sanford J. Shattil, Mark H. Ginsberg, Alex Groisman and Ana Kasirer-Friede,
Lab Chip, 2008, 8, 1486
DOI: 10.1039/b804795b
We developed a microfluidic assay to study the adhesion of platelets from 100 
L mouse blood samples to substrates coated with fibrinogen and collagen in a 100-fold range of shear stresses.
A simple, disposable microfluidic device for rapid protein concentration and purification via direct-printing
Hui Yu, Yu Lu, Yi-ge Zhou, Feng-bin Wang, Feng-yun He and Xing-hua Xia,
Lab Chip, 2008, 8, 1496
DOI: 10.1039/b802778a
The device nanostructures were made by applying a breakdown voltage across the toner gap between two microchannels, attaining protein preconcentration factors up to 105; impurities with opposite charges to the nanofissures can be removed.
On-chip screening method for cell migration genes based on a transfection microarray
Reiko Onuki-Nagasaki, Akira Nagasaki, Kazumi Hakamada, Taro Q. P. Uyeda, Satoshi Fujita, Masato Miyake and Jun Miyake,
Lab Chip, 2008, 8, 1502
DOI: 10.1039/b803879a
On-chip screening method for cell migration genes based on a transfection microarray was developed. NBT-L2b cells would be suitable for screening of cell migration genes without induction of other cellular processes.
A platform for assessing chemotactic migration within a spatiotemporally defined 3D microenvironment
Vinay V. Abhyankar, Michael W. Toepke, Christa L. Cortesio, Mary A. Lokuta, Anna Huttenlocher and David J. Beebe,
Lab Chip, 2008, 8, 1507
DOI: 10.1039/b803533d
We present a method to create long-lasting, stable gradients (upwards of one week) and temporally evolving gradients within the same three-dimensional gel filled environment. We apply this method to study the migratory behavior of cells within the system.
Quantitative and qualitative analysis of a microfluidic DNA extraction system using a nanoporous AlOx membrane
Jungkyu Kim and Bruce K. Gale,
Lab Chip, 2008, 8, 1516
DOI: 10.1039/b804624g
DNA from lysed whole blood is extracted using a nanoporous aluminium oxide membrane embedded in a microfluidic sample preparation system and delivered to a downstream genetic analysis system.
An integrated CMOS high voltage supply for lab-on-a-chip systems
M. Behnam, G. V. Kaigala, M. Khorasani, P. Marshall, C. J. Backhouse and D. G. Elliott,
Lab Chip, 2008, 8, 1524
DOI: 10.1039/b804275f
A compact microelectronic implementation of a high voltage power supply for lab-on-a-chip applications. Microchip electrophoresis with laser induced fluorescence detection is implemented using this mm-scale integrated microelectronic chip.
Electronic control of elastomeric microfluidic circuits with shape memory actuators
Saurabh Vyawahare, Suresh Sitaula, Sujitha Martin, Dvin Adalian and Axel Scherer,
Lab Chip, 2008, 8, 1530
DOI: 10.1039/b804515a
Our platform combines elastomeric chips with shape memory actuators on PCBs. Electronically controlled components like valves, pumps, latches and multiplexers, as well as architectures for microfluidic state control are demonstrated.
Modular microfluidics for gradient generation
Kang Sun, Zongxing Wang and Xingyu Jiang,
Lab Chip, 2008, 8, 1536
DOI: 10.1039/b806140h
Microfluidic modules allow the generation of gradients of complex spatial and temporal profiles with minimum need for microfabrication in the clean room.
Novel one-pot route to monodisperse thermosensitive hollow microcapsules in a microfluidic system
Chang-Hyung Choi, Jae-Hoon Jung, Dong-Wan Kim, Young-Min Chung and Chang-Soo Lee,
Lab Chip, 2008, 8, 1544
DOI: 10.1039/b804839h
A novel and simple approach for the synthesis of monodisperse hollow microcapsules having high thermosensitivity at room temperature, using microfluidic droplet generation with UV-initiated polymerization.
Layer-to-layer parallel fluidic transportation system by addressable fluidic gate arrays
Takashi Morimoto and Satoshi Konishi,
Lab Chip, 2008, 8, 1552
DOI: 10.1039/b804891f
Addressable fluidic gate arrays for layer-to-layer parallel fluidic transportation system are demonstrated by using MEMS technology. Individual gates with pneumatically driven double valves are controlled by row/column addressing.
Polydimethylsiloxane–LiNbO3 surface acoustic wave micropump devices for fluid control into microchannels
Salvatore Girardo, Marco Cecchini, Fabio Beltram, Roberto Cingolani and Dario Pisignano,
Lab Chip, 2008, 8, 1557
DOI: 10.1039/b803967d
Microfluidic devices made from piezoelectric LiNbO3 and polydimethylsiloxane, enabling withdrawing micropumping in microchannels by acoustic radiation.
Room temperature UV adhesive bonding of CE devices
Susan Carroll, Mark M. Crain, John F. Naber, Robert S. Keynton, Kevin M. Walsh and Richard P. Baldwin,
Lab Chip, 2008, 8, 1564
DOI: 10.1039/b805554h
Stamp-and-stick adhesive bonding provides an attractive alternative to conventional thermal bonding. It is simpler, faster, and more reliable and allows the incorporation of temperature-sensitive materials and structures.
Flexible fluidic microchips based on thermoformed and locally modified thin polymer films
R. Truckenmüller, S. Giselbrecht, C. van Blitterswijk, N. Dambrowsky, E. Gottwald, T. Mappes, A. Rolletschek, V. Saile, C. Trautmann, K.-F. Weibezahn and A. Welle,
Lab Chip, 2008, 8, 1570
DOI: 10.1039/b803619e
We present a new approach for the manufacture of fluidic microchips and their application to 3D cell cultivation.
Fluorescent liquid-core/air-cladding waveguides towards integrated optofluidic light sources
Jong-Min Lim, Se-Heon Kim, Jae-Hoon Choi and Seung-Man Yang,
Lab Chip, 2008, 8, 1580
DOI: 10.1039/b805341c
A novel and efficient fluorescent fluidic waveguide with liquid-core/air-cladding configuration suitable for integrated optofluidic light sources.
Back matter
Lab Chip, 2008, 8, 1586
DOI: 10.1039/b813277c
Back cover
Lab Chip, 2008, 8, 1587
DOI: 10.1039/b813278j
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