Contents list for Lab on a Chip, issue 4, 2007
Petra Dittrich reviews the current literature in miniaturisation and related technologies.
A simple pneumatic setup for driving microfluidics
Thomas Braschler, Lynda Metref, Ronit Zvitov–Marabi, Harald van Lintel, Nicolas Demierre, Joël Theytaz and Philippe Renaud, Lab Chip, 2007, 7, 420
We present a simple pneumatic setup for easy and precise control of pairs of inlet flows for lab on a chip applications.
A review of lab-on-a-chip techniques for the analysis of single mammalian cells.
Investigation of heterogeneous electrochemical processes using multi-stream laminar flow in a microchannel
Melissa S. Hasenbank, Elain Fu, Jeffrey B. Nelson, Daniel T. Schwartz and Paul Yager, Lab Chip, 2007, 7, 441
A multi-stream microfluidic system with patterned conductive substrates can be used to produce a visual signature of a complex electrochemical reaction sequence.
Vascular mimetics based on microfluidics for imaging the leukocyte–endothelial inflammatory response
Ulrich Y. Schaff, Malcolm M. Q. Xing, Kathleen K. Lin, Ning Pan, Noo Li Jeon and Scott I. Simon, Lab Chip, 2007, 7, 448
We describe the development and application of a vacuum bonded PDMS flow chamber designed to observe leukocyte–endothelial interactions under defined shear stress.
Single-cell electroporation arrays with real-time monitoring and feedback control
Michelle Khine, Cristian Ionescu-Zanetti, Andrew Blatz, Lee-Ping Wang and Luke P. Lee, Lab Chip, 2007, 7, 457
Feedback controlled electroporation of an array of single-cells, with real-time monitoring, is demonstrated.
On-chip generation of microbubbles as a practical technology for manufacturing contrast agents for ultrasonic imaging
Kanaka Hettiarachchi, Esra Talu, Marjorie L. Longo, Paul A. Dayton and Abraham P. Lee, Lab Chip, 2007, 7, 463
Microfluidics enables the efficient production of custom-designed and stable micron-sized ultrasound contrast agents. Compared to the polydispersity of market leading contrast agents, a vastly improved size distribution is achieved through flow-focusing.
A feasible approach to all-electronic digital labeling and readout for cell identification
D. K. Wood, G. B. Braun, J.-L. Fraikin, L. J. Swenson, N. O. Reich and A. N. Cleland, Lab Chip, 2007, 7, 469
Digital barcodes for cell labeling and detection with high-bandwidth electronic detector yields more than 1000 labels s–1 throughput.
Active 3-D microscaffold system with fluid perfusion for culturing in vitro neuronal networks
Laura Rowe, Mahmoud Almasri, Kil Lee, Nick Fogleman, Gregory J. Brewer, Yoonkey Nam, Bruce C. Wheeler, Jelena Vukasinovic, Ari Glezer and A. Bruno Frazier, Lab Chip, 2007, 7, 475
This work presents the design, fabrication, packaging, and characterization of an active microscaffold system with fluid perfusion/nutrient delivery functionalities for culturing in vitro neuronal networks.
Confinement and deposition of solution droplets on solvophilic surfaces using a flat high surface energy guide
Michal Tencer, Robert Charbonneau and Pierre Berini, Lab Chip, 2007, 7, 483
A method of depositing small amounts of solution on flat micron scale surface areas on a hydrophilic substrate or die was developed.
Concentration and binary separation of micro particles for droplet-based digital microfluidics
Sung Kwon Cho, Yuejun Zhao and Chang-Jin CJ Kim, Lab Chip, 2007, 7, 490
The paper describes a new class of particle separation and concentration for digital (droplet-based) microfluidics: (a) two types of particles mixed in a droplet, (b) separate the particles by an electric field, (c) physically split the droplet by EWOD (electrowetting-on-dielectric), and (d) transport the daughter droplet by EWOD.
Low temperature bonding of PMMA and COC microfluidic substrates using UV/ozone surface treatment
C. W. Tsao, L. Hromada, J. Liu, P. Kumar and D. L. DeVoe, Lab Chip, 2007, 7, 499
Room temperature bonding of PMMA and COC polymer microfluidics is achieved using a simple UV/ozone surface modification process, with exceptionally high bond forces and negligible channel deformation.
Two-layered metallic film-induced surface plasmon polariton for fluorescence emission enhancement in on-chip waveguide
Biow Hiem Ong, Xiaocong Yuan, Yong Yi Tan, Rudi Irawan, Xiaoqin Fang, Lesheng Zhang and Swee Chuan Tjin, Lab Chip, 2007, 7, 506
The surface plasmon (SP) wave penetration depth is extended by employing a bimetallic silver–gold transducing film. The enhanced SP wave is employed for fluorescence excitation, achieving a 4× improvement in collected intensity.
Microfabricated embryonic stem cell divider for large-scale propagation of human embryonic stem cells
Minseok S. Kim, Janghwan Kim, Hyo-Won Han, Yee Sook Cho, Yong-Mahn Han and Je-Kyun Park, Lab Chip, 2007, 7, 513
This paper describes a novel method for fabricating an embryonic stem cell divider (ESCD) constructed from a poly(dimethylsiloxane) replica with a square or hexagonal pattern capable of dissociating human embryonic stem cell (ESC) colonies into regular-sized ESC clumps.
On-chip erythrocyte deformability test under optical pressure
Won Gu Lee, Hyunwoo Bang, Hoyoung Yun, Joonmo Lee, Junha Park, Jung Kyung Kim, Seok Chung, Keunchang Cho, Chanil Chung, Dong-Chul Han and Jun Keun Chang, Lab Chip, 2007, 7, 516
A novel method for an on-chip erythrocyte deformability test under optical pressure, in particular to enhance the sensitivity level with respect to the detection of cancerous diseases.
Fabrication of planar nanofluidic channels in a thermoplastic by hot-embossing and thermal bonding
Patrick Abgrall, Lee-Ngo Low and Nam-Trung Nguyen, Lab Chip, 2007, 7, 520
A technology for fabrication of thermoplastic nanochannels is demonstrated. The combination of molding techniques and conventional lithography make this technology suitable for both prototyping and mass-production of nanofluidic devices at a low-cost.
Non-fouling microfluidic chip produced by radio frequency tetraglyme plasma deposition
Malinda Salim, Gautam Mishra, Gregory J. S. Fowler, Brian O'Sullivan, Phillip C. Wright and Sally L. McArthur, Lab Chip, 2007, 7, 523
We present the direct surface modification of a glass/PTFE hybrid microfluidic chip, via radio frequency glow discharge plasma polymerisation of tetraglyme, to produce non-fouling, hydrophilic PEO-like surfaces with high stability.