Issue 2, 2005
From the journal:

Lab on a Chip

Acoustic micromachining of three-dimensional surfaces for biological applications†

Emilia Entcheva*ab  and  Harold Biena  

* Corresponding authors

a Department of Biomedical Engineering, Stony Brook University, HSC T18-030, Stony Brook, NY 11794-8181, USA
E-mail: emilia.entcheva@sunysb.edu
Fax: (631) 444 6646
Tel: (631) 444 2368

b Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794, USA

Abstract

We present the use of an accessible micromachining technique (acoustic micromachining) for manufacturing micron-feature surfaces with non-discretely varying depth. Acoustic micromachining allows for non-photolithographic production of metal templates with programmable spatial patterns and involves the use of standard acoustic, cutting and electroplating equipment for mass production of vinyl records. Simple 3D patterns were transferred from an acoustic signal into working nickel templates, from which elastic polymer molds were obtained, featuring deep surface grooves and non-discrete (smooth) variations in the z-dimension. Versatility and applicability of the method is demonstrated in obtaining microfluidics structures, manufacturing high-surface area wavy polymer fibers, assembly of cell networks on scaffolds with 3D topography, and microcontact printing of proteins and cells.

Graphical abstract: Acoustic micromachining of three-dimensional surfaces for biological applications

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Article information

DOI
https://doi.org/10.1039/B409478F
Article type
Paper
Submitted
22 Jun 2004
Accepted
05 Oct 2004
First published
22 Nov 2004

Lab Chip, 2005,5, 179-183

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Acoustic micromachining of three-dimensional surfaces for biological applications

E. Entcheva and H. Bien, Lab Chip, 2005, 5, 179 DOI: 10.1039/B409478F

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