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Microfluidic & nanofluidic technologies for chemistry, physics, biology, and bioengineering



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Technical Note

Lab Chip, 2008, 8, 983 - 987, DOI: 10.1039/b717710k

Rapid microfabrication of solvent-resistant biocompatible microfluidic devices

Lung-Hsin Hung, Robert Lin and Abraham Phillip Lee

This paper presents a rapid, simple, and low-cost fabrication method to prepare solvent resistant and biocompatible microfluidic devices with three-dimensional geometries. The devices were fabricated in thiolene and replicated from PDMS master with high molding fidelity. Good chemical compatibility for organic solvents allows volatile chemicals in synthesis and analysis applications. The surface can be processed to be hydrophobic or hydrophilic for water-in-oil and oil-in-water emulsions. Monodisperse organic solvent droplet generation is demonstrated to be reproducible in thiolene microchannels without swelling. The thiolene surface prevents cell adhesion but normal cell growth and adhesion on glass substrates is not affected by the adjacent thiolene patterns.

Graphical abstract image for this article (ID: b717710k)