Issue 6, 2008
From the journal:

Lab on a Chip

Rapid microfabrication of solvent-resistant biocompatible microfluidic devices†

Lung-Hsin Hung,a   Robert Lina  and  Abraham Phillip Lee*ab  

* Corresponding authors

a Department of Biomedical Engineering, University of California at Irvine, 3120 Natural Sciences II, Irvine, CA, USA

b Department of Mechanical and Aerospace Engineering, University of California at Irvine, 3120 Natural Sciences II, Irvine, CA, USA
E-mail: lhung@uci.edu, aplee@uci.edu
Fax: 1-949-8241727
Tel: 1-949-8249691

Abstract

This paper presents a rapid, simple, and low-cost fabrication method to prepare solvent resistant and biocompatible microfluidic devices with three-dimensional geometries. The devices were fabricated in thiolene and replicated from PDMS master with high molding fidelity. Good chemical compatibility for organic solvents allows volatile chemicals in synthesis and analysis applications. The surface can be processed to be hydrophobic or hydrophilic for water-in-oil and oil-in-water emulsions. Monodisperse organic solvent droplet generation is demonstrated to be reproducible in thiolene microchannels without swelling. The thiolene surface prevents cell adhesion but normal cell growth and adhesion on glass substrates is not affected by the adjacent thiolene patterns.

Graphical abstract: Rapid microfabrication of solvent-resistant biocompatible microfluidic devices

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Article information

DOI
https://doi.org/10.1039/B717710K
Article type
Technical Note
Submitted
15 Nov 2007
Accepted
11 Mar 2008
First published
08 Apr 2008

Lab Chip, 2008,8, 983-987

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Rapid microfabrication of solvent-resistant biocompatible microfluidic devices

L. Hung, R. Lin and A. P. Lee, Lab Chip, 2008, 8, 983 DOI: 10.1039/B717710K

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