Technical Note

Lab Chip, 2008, 8, 979 - 982, DOI: 10.1039/b801033a

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Nano-biopower supplies for biomolecular motors: the use of metabolic pathway-based fuel generating systems in microfluidic devices

Joshua R. Wasylycia, Svetlana Sapelnikova, Hyuk Jeong, Jelena Dragoljic, Sandra L. Marcus and D. Jed Harrison

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We report fuel generation systems for molecular motors based on pyruvate kinase, or for the first time, mitochondria, implemented within microfluidic devices. Intact organelles acted as bio-nanopower supplies for molecular motors, using isolated mitochondria to convert chemical energy from succinate to ATP, harnessing nature's enzymatic transformation cascades directly. Motors were activated essentially equally by ATP produced by pyruvate kinase, mitochondria, or direct addition of ATP.

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