Issue 14, 2009
From the journal:

Lab on a Chip

Spheroid array of fetal mouse liver cells constructed on a PEG-gel micropatterned surface: upregulation of hepatic functions by co-culture with nonparenchymal liver cells†

Ryota Kojima,a   Keitaro Yoshimoto,abc   Emiko Takahashi,a   Masahiro Ichino,a   Hirotoshi Miyoshide  and  Yukio Nagasaki*abcdf  

* Corresponding authors

a Graduate School of Pure and Applied Science, University of Tsukuba, 1-1-1 Ten-noudai, Tsukuba, Ibaraki, Japan

b Center for Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 1-1-1 Ten-noudai, Tsukuba, Ibaraki, Japan

c Tsukuba Research Center for Interdisciplinary Materials Science (TIMS), University of Tsukuba, 1-1-1 Ten-noudai, Tsukuba, Ibaraki, Japan

d Master's School of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Ten-noudai, Tsukuba, Ibaraki, Japan

e Department of Biomedical Engineering, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Ten-noudai, Tsukuba, Ibaraki, Japan

f Satellite Laboratory, International Center for Materials Nanoarchitectonics (MANA), National Institute of Materials Science (NIMS), 1-1-1 Ten-noudai, Tsukuba, Ibaraki, Japan

Abstract

A spheroid array of fetal mouse liver cells, which comprise various immature cells, was constructed on a PEG-gel micropatterned surface and its hepatic activity and degree of differentiation induction were significantly upregulated by co-culture with nonparenchymal liver cells as feeder-cells.

Graphical abstract: Spheroid array of fetal mouse liver cells constructed on a PEG-gel micropatterned surface: upregulation of hepatic functions by co-culture with nonparenchymal liver cells

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Article information

DOI
https://doi.org/10.1039/B903388B
Article type
Communication
Submitted
17 Feb 2009
Accepted
18 May 2009
First published
28 May 2009

Lab Chip, 2009,9, 1991-1993

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Spheroid array of fetal mouse liver cells constructed on a PEG-gel micropatterned surface: upregulation of hepatic functions by co-culture with nonparenchymal liver cells

R. Kojima, K. Yoshimoto, E. Takahashi, M. Ichino, H. Miyoshi and Y. Nagasaki, Lab Chip, 2009, 9, 1991 DOI: 10.1039/B903388B

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