Issue 24, 2009
From the journal:

Lab on a Chip

“Print-n-Shrink” technology for the rapid production of microfluidic chips and protein microarrays†

Kevin Sollier,a   Céline A. Mandon,a   Kevin A. Heyries,a   Loïc J. Bluma  and  Christophe A. Marquette*a  

* Corresponding authors

a Laboratoire de Génie Enzymatique et Biomoléculaire, Institut de Chimie et Biochimie Moléculaire et Supramoléculaire, Université Lyon1 – CNRS 5246 ICBMS, Bat. CPE – 43 Bd du 11 Nov, Villeurbanne, France
E-mail: christophe.marquette@univ-lyon1.fr
Fax: +334 72 44 79 70
Tel: +334 72 43 14 84

Abstract

An innovative method for the production of microfluidic chips integrating protein spots is described. The technology, called “Print-n-Shrink”, is based on the screen-printing of a microfluidic design (using a dielectric ink) onto Polyshrink™ polystyrene sheets. The initial print which has a minimum size of 15 µm (height) × 230 µm (width) is thermally treated (30 seconds, 163 °C) to shrink and generate features of 85 µm (height) × 100 µm (width). Concomitantly, proteins such as monoclonal antibodies or cellular adhesion proteins are spotted onto the Polyshrink™ sheets and shrunk together with the microfluidic design, creating a complete biochip integrating both complex microfluidic designs and protein spots for bioanalytical applications.

Graphical abstract: “Print-n-Shrink” technology for the rapid production of microfluidic chips and protein microarrays

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Article information

DOI
https://doi.org/10.1039/B913253H
Article type
Paper
Submitted
03 Jul 2009
Accepted
08 Sep 2009
First published
06 Oct 2009

Lab Chip, 2009,9, 3489-3494

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“Print-n-Shrink” technology for the rapid production of microfluidic chips and protein microarrays

K. Sollier, C. A. Mandon, K. A. Heyries, L. J. Blum and C. A. Marquette, Lab Chip, 2009, 9, 3489 DOI: 10.1039/B913253H

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