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A new high quality chemical biology journal with a particular focus on the interface between chemistry and the -omic sciences and systems biology.
Cover Gallery
Molecular systems biology of ErbB1 receptor-mediated signaling: multiscale model treats processes with disparate length and time-scales in order to predict the effect of somatic mutations on signaling characteristics.
DOI: 10.1039/B819140A
Droplet interface bilayers (DIBs) provide a superior platform for the biophysical analysis of membrane proteins. The versatile DIBs can also form networks, with features that include built-in batteries and sensors.
DOI: 10.1039/B819139P
The main image, designed by Nina Y Yao, illustrates replisome dynamics and the use of DNA trombone loops to bypass replication blocks. Inset is a picture of Professor Bruce Alberts helping to bring science to life in a San Francisco school.
DOI: 10.1039/B811097B
The image shows Arabidopsis thaliana against a background of various intermediates invoved in sulfur metabolism in this organism, investigated using integrated -omics strategies.
DOI: 10.1039/b802911n
The Pseudomonas aeruginosa strain PA01 produces the blue/green phenazine pigment pyocyanin in response to 2-alkyl-4-quinolone (AQ) signal molecules (foreground). In contrast, a mutant unable to synthesize AQs is defective in pyocyanin production (background).
DOI: 10.1039/B803796P
Depiction of non-coding RNA transcripts emanating from immunoglobulin alleles before V(D)J recombination - this intergenic transcription is believed to contribute to opening up the chromatin in these multigene loci. The red signal is a control non-coding transcript, a so called 'supergene' that is continuously transcribed, while the green signals represent V region antisense intergenic transcripts.
DOI: 10.1039/B811123P
Schematic of polypeptide-DNA complexes entering cells where they are reduced to liberate the DNA payload. AFM of polypeptide-DNA complexes before (left-hand side) and after (right-hand side) reduction are shown below.
DOI: 10.1039/B809341P
Chemical synthesis of membrane (-associated) proteins can be achieved by native chemical ligation of peptide segments. The assembled proteins integrate into lipid bilayers where electrophysiological and fluorescence analysis can take place.
DOI: 10.1039/B809340G
Bifunctional Q1 molecules evade cytochrome P450 metabolism by forming protective complexes with FK506-binding protein.
DOI: 10.1039/B807535M
An epifluorescent (ex 590 nm) image of the marine sponge Dysidea herbacea overlaid with MALDI-TOF MS results showing the prescence and localization of two different metabolite ions, depicted in blue and green.
DOI: 10.1039/B807534B
A BLASTatlas visualisation comparing bacterial genomes to a reference chromosome.
DOI: 10.1039/B717118H
A miniaturized PAGE device is shown which performs protein analysis in approximately 10 minutes.
DOI: 10.1039/B716850K
Depiction of metabolome changes in histidine-starved Escherichia coli by CE-TOFMS.
DOI: 10.1039/B800318C
Potential roles of abundant extracellular chaperones in the control of amyloid formation and toxicity.
DOI: 10.1039/B718360G
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