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Molecular BioSystems

Research at the interface between chemistry and the -omic sciences and systems biology.



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Mol. BioSyst., 2009, 5, 1456 - 1472, DOI: 10.1039/b906402h

Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics

Semin Lee, Alan Brown, William Ross Pitt, Alicia Perez Higueruelo, Sungsam Gong, George Richard Bickerton, Adrian Schreyer, Duangrudee Tanramluk, Alison Baylay and Tom Leon Blundell

Here we review the use of informatics in structural interactomics, with particular emphasis on understanding interfacial contacts in the development of novel therapeutics and the interpretation of genetic variation. We describe the availability and applicability of structural databases of protein interactions which facilitate this endeavour. We demonstrate the applicability of a structural interactomics approach to the study of the fibroblast growth factor (FGF)-stimulated mitogen-activated protein kinase (MAPK) pathway.

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