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Molecular BioSystems

Research at the interface between chemistry and the -omic sciences and systems biology.



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Review

Mol. BioSyst., 2005, 1, 127 - 134, DOI: 10.1039/b504392a

Disulfiram, an old drug with new potential therapeutic uses for human cancers and fungal infections

Zuben E. Sauna, Suneet Shukla and Suresh V. Ambudkar

Disulfiram, a drug used to treat alcoholism, has recently been indicated to play a primary as well as an adjuvant role in the treatment of many cancers and in the reversal of fungal drug-resistance. This review discusses the molecular mechanism of action of disulfiram and its potential use in the treatment of human cancers and fungal infections.

Graphical abstract image for this article (ID: b504392a)