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Research at the interface between chemistry and the -omic sciences and systems biology.
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Mol. BioSyst., 2007, 3, 458 - 465, DOI: 10.1039/b705624a
Inhibition of lysine biosynthesis: an evolving antibiotic strategy
Craig A. Hutton, Matthew A. Perugini and Juliet A. Gerrard
Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel antibacterial agents as it provides lysine for protein synthesis and both lysine and meso-diaminopimelate for construction of the bacterial peptidoglycan cell wall. In this Highlight article we review recent advances in the validation of antibiotic targets, studies of the enzymes of the lysine biosynthetic pathway and development of inhibitors of these enzymes.
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