Issue 2, 2006
From the journal:

New Journal of Chemistry

End group engineering of artificial ion channels

François Otis,a   Normand Voyer,*a   Ange Polidorib  and  Bernard Puccib  

* Corresponding authors

a Département de Chimie and Centre de Recherche sur la fonction, la structure et l’ingénierie des protéines, Faculté des sciences et de génie, Université Laval, Québec, Canada
E-mail: normand.voyer@chm.ulaval.ca
Fax: +1-418-656-7916
Tel: 1-418-656-3613

b Laboratoire de Chimie Bioorganique et des Systèmes Moléculaires Vectoriels, Faculté des sciences, Université d’Avignon, 33, rue Louis Pasteur, Avignon, France

Abstract

Toward developing nanostructures for single molecule detection, we report the synthesis of new derivatives of artificial devices that possess ion channel activity. The membrane stability and the ion transport ability of these multiple crown α-helical peptides have been optimized by modulating the polarity of N- and C-terminal groups with incorporation of hydrophilic non-ionic units. Circular dichroism and ATR studies confirmed the α-helical conformation and membrane incorporation of new nanostructures while 23Na NMR assays shown a significant increase of their ion transport ability.

Graphical abstract: End group engineering of artificial ion channels

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Article information

DOI
https://doi.org/10.1039/B509668E
Article type
Paper
Submitted
12 Jul 2005
Accepted
11 Aug 2005
First published
01 Sep 2005

New J. Chem., 2006,30, 185-190

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End group engineering of artificial ion channels

F. Otis, N. Voyer, A. Polidori and B. Pucci, New J. Chem., 2006, 30, 185 DOI: 10.1039/B509668E

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