Issue 1, 2009
From the journal:

Nanoscale

Label-free SERS detection of relevant bioanalytes on silver-coated carbon nanotubes: The case of cocaine†

Marcos Sanles-Sobrido,a   Laura Rodríguez-Lorenzo,a   Silvia Lorenzo-Abalde,b   África González-Fernández,b   Miguel A. Correa-Duarte,*a   Ramón A. Alvarez-Puebla*a  and  Luis M. Liz-Marzána  

* Corresponding authors

a Departamento de Química Física and Unidad Asociada CSIC, Universidade de Vigo, 36310 Vigo, Spain
E-mail: macorrea@uvigo.es, ramon.alvarez@uvigo.es

b Grupo de Inmunología, Universidade de Vigo, 36310 Vigo, Spain

Abstract

Surface-enhanced Raman scattering (SERS) spectroscopy can be used for the label-free determination and quantification of relevant small biometabolites that are hard to identify by conventional immunological methods, in the absence of labelling. In this work, detection is based on monitoring the vibrational changes occurring at a specific biointerface (a monoclonal antibody, mAb) supported on silver-coated carbon nanotubes (CNT@Ag). Engineered CNT@Ag play a key role, as they offer a stable substrate to support the biointerface, with a high density of hot spots. Proof of concept is demonstrated through the analysis and quantification of the main cocainemetabolitebenzoylecgonine. These results open a new avenue toward the generation of portable sensors for fast ultradetection and quantification of relevant metabolites. The use of discrete particles (CNT@Ag@mAb) rather than rough films, or other conventional SERS supports, will also enable a safe remote interrogation of highly toxic sources in environmental problems or in biological fluids.

Graphical abstract: Label-free SERS detection of relevant bioanalytes on silver-coated carbon nanotubes: The case of cocaine

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Article information

DOI
https://doi.org/10.1039/B9NR00059C
Article type
Paper
Submitted
10 Mar 2009
Accepted
22 Jun 2009
First published
13 Aug 2009

Nanoscale, 2009,1, 153-158

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Label-free SERS detection of relevant bioanalytes on silver-coated carbon nanotubes: The case of cocaine

M. Sanles-Sobrido, L. Rodríguez-Lorenzo, S. Lorenzo-Abalde, Á. González-Fernández, M. A. Correa-Duarte, R. A. Alvarez-Puebla and L. M. Liz-Marzán, Nanoscale, 2009, 1, 153 DOI: 10.1039/B9NR00059C

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