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Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.




Paper

Org. Biomol. Chem., 2005, 3, 3184 - 3187, DOI: 10.1039/b507028g


A straightforward approach towards thiazoles and endothiopeptides via Ugi reaction

Uli Kazmaier and Stefanie Ackermann


Endothiopeptides can easily be obtained via Ugi reaction using thio acids as acid components. If isonitriles with an acetal group are applied, the endothiopeptides can directly be converted into thiazoles using TMSCl–NaI under microwave irradiation.

Graphical abstract image for this article  (ID: b507028g)