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Org. Biomol. Chem., 2007, 5, 2753 - 2755, DOI: 10.1039/b708884c

Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product—a further simplification of the lactone region

Simon J. Shaw, Hugo G. Menzella, David C. Myles, Ming Xian and Amos B. Smith III

Analogues of discodermolide in which the complete C-1 to C-7 fragment is replaced with a coumarin moiety display equivalent potency to that of the natural product.

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