Issue 6, 2004

Use of a Design of Experiments approach for the optimisation of a microwave assisted Ugi reaction

Abstract

The utility of a Design of Experiments (DoE) approach for the rapid and efficient optimisation of a microwave assisted Ugi 3cc reaction of levulinic acid is demonstrated. DoE methods have also been applied to the assessment of the reaction scope for a range of amine and isonitrile substrates. The optimal procedure developed using this approach has enabled the preparation of lactam derivatives in moderate to excellent yields (17–90%) in a reaction time of only 30 min compared to the conventional methodology which required up to 48 h.

Graphical abstract: Use of a Design of Experiments approach for the optimisation of a microwave assisted Ugi reaction

Article information

Article type
Communication
Submitted
09 Jan 2004
Accepted
03 Feb 2004
First published
09 Feb 2004

Org. Biomol. Chem., 2004,2, 813-815

Use of a Design of Experiments approach for the optimisation of a microwave assisted Ugi reaction

H. Tye and M. Whittaker, Org. Biomol. Chem., 2004, 2, 813 DOI: 10.1039/B400298A

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