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Communication
Org. Biomol. Chem., 2004, 2, 813 - 815, DOI: 10.1039/b400298a
Use of a Design of Experiments approach for the optimisation of a microwave assisted Ugi reaction
Heather Tye and Mark Whittaker
The utility of a Design of Experiments (DoE) approach for the rapid and efficient optimisation of a microwave assisted Ugi 3cc reaction of levulinic acid is demonstrated. DoE methods have also been applied to the assessment of the reaction scope for a range of amine and isonitrile substrates. The optimal procedure developed using this approach has enabled the preparation of lactam derivatives in moderate to excellent yields (17–90%) in a reaction time of only 30 min compared to the conventional methodology which required up to 48 h.
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