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Communication
Org. Biomol. Chem., 2004, 2, 1822 - 1824, DOI: 10.1039/b405882h
Remarkable effect of tris(4-fluorophenyl)phosphine oxide on the stabilization of chiral lanthanum complex catalysts. A new and practical protocol for the highly enantioselective epoxidation of conjugated enones
Rie Kino, Kazuhiro Daikai, Toshio Kawanami, Hiroshi Furuno and Junji Inanaga
A new and efficient chiral catalyst system, lanthanum–chiral BINOL–tris(4-fluorophenyl)phosphine oxide–cumene hydroperoxide, was developed for the epoxidation of
,
-unsaturated ketones thus providing the corresponding epoxy ketones with excellent enantioselectivities (up to >99% ee) in good to excellent yields at room temperature.
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