Issue 6, 2005
From the journal:

Organic & Biomolecular Chemistry

Synthesis and characterisation of highly emissive and kinetically stable lanthanide complexes suitable for usage ‘in cellulo’

Robert A. Poole,a   Gabriella Bobba,a   Martin J. Cann,b   Juan-Carlos Frias,a   David Parker*a  and  Robert D. Peacockc  

* Corresponding authors

a Department of Chemistry, University of Durham, South Road, Durham, UK

b Department of Biological Sciences, University of Durham, South Road, Durham, UK

c Department of Chemistry, University of Glasgow, Glasgow, UK

Abstract

The synthesis and photophysical characterisation are reported of a series of cationic, neutral and anionic europium and terbium complexes based on structurally related, nonadentate ligands based on the cyclen macrocycle. Each complex incorporates a tetraazatriphenylene moiety and overall absolute emission quantum yields are in the range 15–40% in aerated aqueous media. Dynamic quenching of the lanthanide excited state occurs with electron-rich donors, e.g. iodide, ascorbate and urate, and a mechanistic interpretation is put forward involving an electron transfer process. The cationic lanthanide complexes are taken up by NlH/3T3 cells and tend to localise inside the cell nucleus.

Graphical abstract: Synthesis and characterisation of highly emissive and kinetically stable lanthanide complexes suitable for usage ‘in cellulo’

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Article information

DOI
https://doi.org/10.1039/B418964G
Article type
Paper
Submitted
20 Dec 2004
Accepted
19 Jan 2005
First published
02 Mar 2005

Org. Biomol. Chem., 2005,3, 1013-1024

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Synthesis and characterisation of highly emissive and kinetically stable lanthanide complexes suitable for usage ‘in cellulo’

R. A. Poole, G. Bobba, M. J. Cann, J. Frias, D. Parker and R. D. Peacock, Org. Biomol. Chem., 2005, 3, 1013 DOI: 10.1039/B418964G

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