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Organic & Biomolecular Chemistry

The international home of synthetic, physical and biomolecular organic chemistry.




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Org. Biomol. Chem., 2006, 4, 47 - 50, DOI: 10.1039/b512177a


Highly efficient methods for the one-pot synthesis of -substituted enones

William J. Kerr, Colin M. Pearson and Graeme J. Thurston


A mild and practically-convenient one-pot procedure for the direct -substitution of enones has been developed using a conjugate addition–oxidation strategy with a full range of copper-based reagents and N-tert-butylphenylsulfinimidoyl chloride; alkyl- and aryl-substituted enones are delivered in good to excellent yields.

Graphical abstract image for this article  (ID: b512177a)